Dantrolene requires Mg2+ to arrest malignant hyperthermia
نویسندگان
چکیده
منابع مشابه
Dantrolene requires Mg2+ to arrest malignant hyperthermia.
Malignant hyperthermia (MH) is a clinical syndrome of skeletal muscle that presents as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop lethally high body temperatures. Genetic predisposition mainly arises from mutations on the skeletal muscle ryanodine receptor (RyR). Dantrolene is administered to alleviate MH symptoms, but its mechanism of action a...
متن کاملDantrolene sodium and management of malignant hyperthermia.
Malignant hyperthermia (MH) is an inherited muscle disorder suffered by patients who undergo a stressful situation or acute trauma or who have been given certain anesthetic agents. 1,2 MH has been called the most common cause of anesthesiarelated death in North America, contributing a large percentage of the 15,000 to 20,000 of such deaths recorded annually.3 The 53% mortality rate of today com...
متن کاملDantrolene in the treatment of malignant hyperthermia: a case report
Case report The patient, a 19 year old healthy male, who suffered childhood asthma, was anaesthetised for a planned mandible sagittal split and bimaxillar osteotomia due to prognathia. Anaesthesia was induced with propofol 140 mg and suxamethonium 100 mg was administered for muscle relaxation. Relaxation was not optimal but intubation was performed without problems. Anaesthesia was maintained w...
متن کاملMind the magnesium, in dantrolene suppression of malignant hyperthermia.
Malignant hyperthermia (MH) is a pharmacogenetic syndrome wherein exposure to halogenated volatile anesthetics or to depolarizing muscle relaxants during general anesthesia may trigger a life-threatening hypermetabolic state driven by excessive Ca release from the sarcoplasmic reticulum (SR) of skeletal muscle (1). Over 25 y ago, the acute administration of dantrolene was shown to be highly eff...
متن کاملA suspected malignant hyperthermia managed without dantrolene sodium
Corresponding author: Bon-Sung Koo, M.D., Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170, Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea. Tel: 82-32-621-5330, Fax: 82-32-621-5322, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1619835114